An investigation on radiopharmaceutical potantial of I-131 labeled sertraline

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dc.contributor.authorYurt, Fatma
dc.contributor.authorÜnak, Perihan
dc.contributor.authorBiber, F. Zümrüt
dc.contributor.authorID10811tr_TR
dc.contributor.departmentBölüm Yoktr_TR
dc.date.accessioned2018-07-13T08:55:42Z
dc.date.available2018-07-13T08:55:42Z
dc.date.issued2000-10
dc.descriptionI. Avrasya Nükleer Bilimler ve Uygulamaları Konferansı : 23-27 Ekim 2000. İzmir, Türkiye.tr_TR
dc.description.abstractSertraline [(IS- cis)- 4-( 3, 4-dichlorophenyl)-l,2,3,4 -tetrahydro - N-methyl-l-naphalenamine hydrochloride] is an antidepressant drug. It is presumed to be linked to its inhibition of central nervous system (CNS) neuronal uptake of serotonin (5-HT) receptors. Serotonin 5-HT1A receptors are prominently expressed in the CNS that binding sites are present various brain regions. The aim of this study is to label with 1-131 and investigate of its radiopharmaceutical potential. Sertraline was labeled with 1-131 by using iodogen method. Quality Controls were fixed by Radio-TLC and Electrophoresis Methods. Labeling yield was 85-90% and spesific activity was approximately 1.75 Ci/mmol. The purification of radioiodinated Sertraline was performed by Sep Pak C-18 plus and determined radiochemical purity over 99%. Biodistribution studies were carried out by male Albino Wistar rats. 1-131 labeled Sertraline was administered by intravenous injection into tail vein of the rats. The rats were sacrificed by ether narcotization at certain time intervals and the organs were removed. The whole brain was excised quickly and dissected into their regions. Their activities were counted by Cd(Te) detector equipped with RAD 501 Single Channel Analyzer Instrument. The percentage injected radioactivity per gram of tissue was calculated, and these data versus time curves were generated for organs and brain regions. Obtained results showed that 1-131 labeled Sertraline may be a promising radiopharmaceutical for investigation of serotonin 5-HT receptor functions of brain.tr_TR
dc.identifier.citationYurt, F., Ünak, P., Biber, F. Z. (2000). An investigation on radiopharmaceutical potantial of I-131 labeled sertraline. I. Eurasia Conference on Nuclear Science and Its Application, Presentations, Vol 1, (s. 404-409). 23-27 October 2000. İzmir, Turkey.tr_TR
dc.identifier.endpage409tr_TR
dc.identifier.startpage404tr_TR
dc.identifier.urihttp://kurumsalarsiv.tenmak.gov.tr/handle/20.500.12878/721
dc.language.isoengtr_TR
dc.publisherTurkish Atomic Energy Authoritytr_TR
dc.relation.journalI. Eurasia Conference on Nuclear Science and Its Application : Presentations, 23-27 October 2000. İzmir, Turkey.tr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subjectRadiopharmaceuticaltr_TR
dc.subjectRadyofarmasötiktr_TR
dc.subjectSertralinetr_TR
dc.subjectSertralintr_TR
dc.subjectI-131tr_TR
dc.titleAn investigation on radiopharmaceutical potantial of I-131 labeled sertralinetr_TR
dc.typeconferenceObjecttr_TR
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I. Eurasia conference on nuclear science and its application : presentations, 23-27 October 2000. İzmir, Turkey.