Ünak, PerihanYurt, FatmaBiber, F. Zümrüt2018-07-312018-07-312000-10Ünak, P., Yurt, F., Biber, F. Z., (2000). Labeling of chlorodiazepoxide with I-131 and biodistribution studies on rats. I. Eurasia Conference on Nuclear Science and Its Application, Presentations, Vol 1, (s. 581-585). 23-27 October 2000. İzmir, Turkey.http://kurumsalarsiv.tenmak.gov.tr/handle/20.500.12878/751I. Avrasya Nükleer Bilimler ve Uygulamaları Konferansı : 23-27 Ekim 2000. İzmir, Türkiye.Chlordiazepoxide (CDZ) was labeled with I-131 and investigated its radiopharmaceutical potential as a benzodiazepine receptor agent. Iodogen was used as iodination agent. Labeling yields were determined by radio-ITLC (Instant Thin Layer Chromatography) and Paper Electrophoresis. Labeling yield was approximately 90%. Purification were performed by SepPak C-18 plus. Biodistribution studies were carried out by Albino Wistar rats. I-131 labeled Chlordiazepoxide which is the 62.2 GBq/mmol specific activity was administered by tail vein into the rats. Rats were sacrificed by ether narcotization at certain time intervals and the organs were removed. The brains were dissected into their components. Their activities were counted by a gamma counter. The activity per gram tissue was calculated and time activity curves were generatedenginfo:eu-repo/semantics/openAccessRatsFarelerBiodistribution studiesBiyodağılım çalışmalarıLabeling of chlorodiazepoxideKlordiazepoksidin etiketlenmesiI-131Labeling of chlorodiazepoxide with I-131 and biodistribution studies on ratsconferenceObject581585