DNA damage in hair root cells as a biomarker for gamma rays exposure

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dc.contributor.authorTepe Çam, Semra
dc.contributor.authorSeyhan, Nesrin
dc.contributor.departmentTAEK-SANAEMtr_TR
dc.date.accessioned2017-01-31T08:11:25Z
dc.date.available2017-01-31T08:11:25Z
dc.date.issued2013-08-30
dc.description.abstractThe purpose of the present research is to examine whether human hair root cells can be used for dose assessment after in vitro exposure to ionizing radiation. Hair root samples plucked from random head regions were collected from 5 healthy human subjects. Some of these hair samples were used as control and some were irradiated with 0.5 - 5 Gy of gamma ray using a Cs-137 gamma irradiator at a dose rate of 0.14 Gy/sec. DNA damage (single strand break) were determined in hair root cells of these samples using the comet assay technique. The comet assay measurements, tail length (TL) and tail moment (TM) values showed that the irradiation significantly increased (p< .05) single-strand DNA breaks in hair roots cells of the exposed samples compared to control. A linear dose-effect relationship was observed when tail-moment or tail-length was plotted against the log of the radiation dose. This research suggests a possible usage of human hair root cells as a biomarker especially for low dose radiation exposure using the comet assay technique.tr_TR
dc.identifier.citationTepe Çam, S. ve N. Seyhan (2013).DNA damage in hair root cells as a biomarker for gamma rays exposure. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. Volume 756, issues 1–2, 30 August 2013, pages 201-205.tr_TR
dc.identifier.citationhttps://doi.org/10.1016/j.mrgentox.2013.06.011
dc.identifier.endpage205tr_TR
dc.identifier.issn1383-5718tr_TR
dc.identifier.issn1383-5718
dc.identifier.issn1383-5718
dc.identifier.issue1–2tr_TR
dc.identifier.startpage201tr_TR
dc.identifier.urihttp://kurumsalarsiv.tenmak.gov.tr/handle/20.500.12878/245
dc.identifier.volume756tr_TR
dc.language.isoengtr_TR
dc.publisherElsevier B.Vtr_TR
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.mrgentox.2013.06.011tr_TR
dc.relation.journalMutation Research/Genetic Toxicology and Environmental Mutagenesistr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subjectGamma raystr_TR
dc.subjectGama ışınlarıtr_TR
dc.subjectGamma raytr_TR
dc.subjectGama ışınıtr_TR
dc.subjectDNA damagetr_TR
dc.subjectDNA hasarıtr_TR
dc.subjectComet assaytr_TR
dc.subjectComet testitr_TR
dc.subjectRadiation biomarkertr_TR
dc.subjectRadyasyon biyomarkeritr_TR
dc.subjectHair root cellstr_TR
dc.subjectSaç kökü hücreleritr_TR
dc.titleDNA damage in hair root cells as a biomarker for gamma rays exposuretr_TR
dc.typearticletr_TR
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