In vitro investigations of the characteristics of multiple emulsions and their extension of the period of radioprotection afforded by cysteamine (mercaptoethylamine).
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Date
1979-02
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Publisher
Turkish Atomic Energy Commission, Ankara Nuclear Research and Traning Center
Abstract
Hafif sıvı parafin bazlı çok katlı emülsiyonlara tesir eden parametreler, kararlı ve güvenilir emülsiyonlar elde edebilmek için tetkik edilmiş ve böyle bir emülsiyon elde edebilmek için % 7,5 MEA çözeltisi ve birincide % 9.5 arlacel, ikinci emülsiyonda % 0.85 lik fizyolojik sudaki % 2,1 tween ve 1 : 1 oranında karıştırılmış relatif hacimlerdeki emülsiyonların uygun olduğu görülmüştür. Preparatın hazırlanmasından sonraki tatbik zamanının da kritik olduğu gösterilmiştir.
Cysteamine bu emülsiyonla beraber verildiği zaman, bu karışımın farelerde uzun süreli bir koruyucu olarak tesir gösterdiği anlaşılmıştır. Bunların neticeleri de daha ileriki bir çalışmamızda açıklanacaktır.
Parameters which effect the characteristics of light-liquid paraffinbased sustained- release multiple emulsions were investigated in order to obtain stable and reproducible emulsions and it was found that in order to obtain a reproducible stable sustained - release emulsion, the values of 7,5 % MEA solution and 9,5 % arlacel 88 in primary, together with 2,1 % tween in 0.85 % saline in secondary emulsion, and a mixture of 1 : 1 relative volumes to form the final emulsion were suitable. It was also shown that time of injection following the preparation was critical. This emulsion is used in mice to provide long term protection by cysteamine and the results will be published in a further article.
Parameters which effect the characteristics of light-liquid paraffinbased sustained- release multiple emulsions were investigated in order to obtain stable and reproducible emulsions and it was found that in order to obtain a reproducible stable sustained - release emulsion, the values of 7,5 % MEA solution and 9,5 % arlacel 88 in primary, together with 2,1 % tween in 0.85 % saline in secondary emulsion, and a mixture of 1 : 1 relative volumes to form the final emulsion were suitable. It was also shown that time of injection following the preparation was critical. This emulsion is used in mice to provide long term protection by cysteamine and the results will be published in a further article.
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Keywords
In vitro investigations, In vitro araştırmaları, Characteristics of multiple emulsions, Çoklu emülsiyonların özellikleri, Cysteamine (mercaptoethylamine), Sisteamin (merkaptoetilamin), Radioprotection, Radyasyon koruması, Extension, Uzatma
Citation
Birol, E. (1979). In vitro investigations of the characteristics of multiple emulsions and their extension of the period of radioprotection afforded by cysteamine (mercaptoethylamine). Technical Journal, 6(1), 18-28.