Effect of grape seed extract on lipid peroxidation, antioxidant activity and peripheral blood lymphocytes in rats exposed to radiation

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dc.contributor.authorEnginar, Hüseyin
dc.contributor.authorCemek, M.
dc.contributor.authorKaraca, T.
dc.contributor.authorÜnak, Perihan
dc.contributor.authorID58588tr_TR
dc.contributor.departmentBölüm Yoktr_TR
dc.date.accessioned2019-02-13T08:24:20Z
dc.date.available2019-02-13T08:24:20Z
dc.date.issued2006
dc.description.abstractThe radioprotective efficacy of grape seed extract (GSE) and vitamin E against whole body X-radiation was studied in Albino Wistar rats. Three groups of rats were investigated: control group (CG) intraperitoneal (i.p.) physiological serum 1 ml/day (n = 10), i.p., vitamin E group (VG) 50 mg/kg/day (n = 10), and i.p. grape seed extract group 50mg/kg/day (n=10). Four weeks later, 6 Gy radiation dose was given to rats. The blood samples were taken 24 hours later after irradiation and Lymphocyte, malondialdehyde (MDA), reduced glutathione (GSH), nitrate, nitrite, reduced ascorbic acid, retinol, (β-caratone and ceruloplasmin concentrations were analyzed. The levels of GSH (p <0.05), retinol (p <0.001), (β-caratone (p <0.05) and ceruloplasmin concentration (p <0.001) in GSE group were found to be higher than control group but the level of MDA (p <0.001) and nitrite concentration (p <0.05) in rats supplemented with GSE group were found to be lower than the CG. The results show that GSE has enhanced the antioxidant status and have decreased the incidence of free radical- induced lipid peroxidation in blood sample of rats exposed radiation.tr_TR
dc.identifier.citationEnginar, H. ... [ve arkadaşları]. (2006). Effect of grape seed extract on lipid peroxidation, antioxidant activity and peripheral blood lymphocytes in rats exposed to radiation. The Fourth Eurasian Conference on Nuclear Science and Its Application : Presentations, (s. 336-343). 31 October-3 November 2006. Baku, Azerbaijan.tr_TR
dc.identifier.endpage343tr_TR
dc.identifier.startpage336tr_TR
dc.identifier.urihttp://kurumsalarsiv.tenmak.gov.tr/handle/20.500.12878/1084
dc.language.isoengtr_TR
dc.publisherAzerbaijan National Academy of Sciences Institute of Radiation Problems ve Turkish Atomic Energy Authoritytr_TR
dc.relation.journalThe Fourth Eurasian Conference on Nuclear Science and Its Application : Presentations, 31 October-3 November 2006. Baku, Azerbaijan.tr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subjectRadiation exposuretr_TR
dc.subjectRadyasyona maruz kalmatr_TR
dc.subjectRatstr_TR
dc.subjectSıçanlartr_TR
dc.subjectGrape seed extracttr_TR
dc.subjectÜzüm çekirdeği ekstresitr_TR
dc.subjectLipid peroxidationtr_TR
dc.subjectLipid peroksidasyonutr_TR
dc.subjectAntioxidant activitytr_TR
dc.subjectAntioksidan aktivitetr_TR
dc.subjectPeripheral blood lymphocytestr_TR
dc.subjectPeriferal kan lenfositleritr_TR
dc.subjectGrape seedstr_TR
dc.subjectÜzüm çekirdeğitr_TR
dc.subjectX-raystr_TR
dc.subjectX-ışınlarıtr_TR
dc.titleEffect of grape seed extract on lipid peroxidation, antioxidant activity and peripheral blood lymphocytes in rats exposed to radiationtr_TR
dc.typeconferenceObjecttr_TR
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IV. Eurasian conference on nuclear science and its application : presentations, 31 October- 3 November 2006. Baku, Azerbaijan.