Radiation sensitivity and dosimetric features of sultamicillin tosylate : an electron spin resonance study

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dc.contributor.authorTepe Çam, Semra
dc.contributor.authorPolat, Mustafa
dc.contributor.authorKorkmaz, Mustafa
dc.contributor.departmentTAEK-SANAEMtr_TR
dc.date.accessioned2017-02-01T06:54:22Z
dc.date.available2017-02-01T06:54:22Z
dc.date.issued2009
dc.description.abstractParticular interest now centers on the preparation of steril-unit dose preparations. When preparations are purified from microorganisms using classic sterilization techniques, serious degradations may occur especially in temperature sensitive drugs and drug active components. Sultamicillin is the tosylate salt of double ester of sulbactam plus ampicillin. Sultamicillin tosylate (SULT) has previously been shown to be clinically and bacteriologically effective in a variety of infections. The use of high-energy radiation such as gamma rays for the sterilization of pharmaceuticals offers considerable interest because of the clear advantages this process has, compared to other methods of sterilization. However, radiosensitivity of irradiated pharmaceutical is important in this respect. Thus, radiosensitivity of SULT and its potential use as a dosimetric material were investigated by Electron Spin Resonance (ESR) spectroscopy in the present work. Samples of SULT powder were irradiated at doses of 3, 6, 10 and 15 kGy and ESR spectra were recorded at room and at different temperatures. Variations of different spectroscopic parameters with irradiation dose, temperature, and storage time were evaluated using data derived from experimental ESR spectra which exhibited five different resonance peaks. Stabilities of the radiolytic intermediates at high temperatures were also investigated through annealing studies performed at 340, 345 and 350 K. Rapid decrease in the resonance peak heights above 325 K was considered as a manifestation of unstable character of the radiolytical intermediates at high temperature although they decayed relatively slowly at room temperature. Seven different mathematical functions have been tried to fit experimental dose-response data and a power function of the applied dose was found to describe best the dose-response data.tr_TR
dc.identifier.citationTepe Çam, S., Polat, M. ve M. Korkmaz (2009) Radiation sensitivity and dosimetric features of sultamicillin tosylate : an electron spin resonance study, Radiation Effects and Defects in Solids, Volume 164, 2009 - Issue 2, Pages 90-100.tr_TR
dc.identifier.endpage100tr_TR
dc.identifier.issn1042-0150tr_TR
dc.identifier.issue2tr_TR
dc.identifier.startpage90tr_TR
dc.identifier.urihttp://kurumsalarsiv.tenmak.gov.tr/handle/20.500.12878/257
dc.identifier.volume164tr_TR
dc.language.isoengtr_TR
dc.publisherTaylor & Francistr_TR
dc.relation.isversionofhttp://dx.doi.org/10.1080/10420150802574289tr_TR
dc.relation.journalRadiation Effects and Defects in Solidstr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subjectElektron spin rezonansı (ESR)
dc.subjectSultamicillintr_TR
dc.subjectSultamsilintr_TR
dc.subjectRadiostabilitytr_TR
dc.subjectRadyostabilitetr_TR
dc.subjectRadiosterilizationtr_TR
dc.subjectRadyodezikasyontr_TR
dc.subjectRadicaltr_TR
dc.subjectRadikaltr_TR
dc.subjectDosimetrytr_TR
dc.subjectDozimetritr_TR
dc.subjectElectron spin resonance (ESR)tr_TR
dc.titleRadiation sensitivity and dosimetric features of sultamicillin tosylate : an electron spin resonance studytr_TR
dc.typearticletr_TR
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