Makale
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Browsing Makale by ORCID "0000-0002-0403-5425"
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Item A potential new approach for preserving historical artifacts through gamma irradiation and green antimicrobials: Microbiological and theoretical screening(ELSEVIER, 2025-08-16) Ergun, Ece; Halkman, Hilal B.D.; Kasımfırtına, Eren; Kantoğlu, Ömer; Ergun, Ümit; Orhan, ErsinThis study presents a novel combined treatment process for the decontamination of historical textiles, using gamma irradiation with green antimicrobial agents. Microbiological studies and theoretical approaches were utilized to investigate the effect of treatment processes individually and in combination on isolates from the textile museum. The mean D10 values and the required doses for complete inactivation were found to be 1.19 and 7.60 kGy for bacteria cocktail and 1.47 and 6.32 kGy for mold cocktail, respectively. The antimicrobial activities of two Schiff bases and their reduced derivatives were tested against gamma-resistant microorganisms by measuring the diameter of the inhibition zones. It was found that reduced derivatives exhibited higher antibacterial activity. All compounds were screened through an in-silico study to evaluate the physicochemical properties, drug-likeness, and toxicity profile. Molecular docking studies were performed to investigate the binding affinity of the title compounds against E. coli DNA gyrase B and topoisomerase IV. From the perspectives of both in vitro studies and computational analysis, L4 exhibited the highest biological activity. This finding revealed that the reduction of the imine bond and molecular flexibility have a significant influence on binding to the active site of the biomolecule. Finally, the combined treatment utilizing L4 with gamma irradiation demonstrated a synergistic effect, leading to a 2.6-fold reduction compared to the control, whereas the individual treatments of L4 and gamma irradiation exhibited approximately a 1-fold reduction. This synergistic effect presents an innovative approach to the historical artifact preservation, providing a more efficient and potentially safer decontamination strategy.Item Assessment of low-energy electron beam irradiation for effective surface microbial decontamination of fresh lettuce (Lactuca sativa L.) leaves(ELSEVIER, 2025-05-12) Turan, Ozlem; Cetintas, Aydin Ozan; Gokalp, Metin; Halkman, Hilal Beyhan; Ic, Erhan; Kantoglu, Omer; Kantoglu, Kadriye YaprakMicrobial contamination in fresh produce, particularly leafy greens such as lettuce and spinach, constitutes a significant public health concern due to infections caused by enteropathogens. Therefore, low-energy electron beam (LEEB) irradiation has been introduced to ensure microbial decontamination, analogous to conventional irradiation applications. This study examines the efficacy of LEEB irradiation in reducing bacterial contamination in lettuce (Lactuca sativa L.) and determines the radiation sensitivity of target microorganisms through D10 values compares it with the gamma-ray treatment. Hydroponically cultivated lettuce samples were inoculated with Escherichia coli, Salmonella Enteritidis, Listeria monocytogenes, and E. coli O157:H7. Following LEEB treatment, the D10 values of four pathogens were calculated between 0.371, and 0.737 kGy, whereas gamma irradiation resulted in lower values of 0.262-0.327 kGy. These results suggest that LEEB doses in the range of approximately 1.7 to 3 kGy may be sufficient to achieve an average 4-log reduction in pathogens. Additionally, the effects of LEEB irradiation on the physicochemical properties of lettuce were evaluated immediately after irradiation at doses of 1, 3, and 5 kGy. While no statistically significant differences were observed in color and total vitamin C (p>0.05), bioactive compound levels increased at higher doses (p<0.05). Fourier Transform Infrared (FT-IR) spectroscopy confirmed minimal structural alterations. These findings suggest that LEEB irradiation effectively decontaminates lettuce while maintaining its physicochemical integrity and enhancing its bioactive properties, presenting a promising and very important approach for improving fresh produce safety.Item Efficacy of radiation technologies in reducing microbial contamination in hospital wastewater(Springer, 2026-02-14) Genç, Ayşenur; Ergun, Ece; İnce, Elif; İnce, Mahir; Kantoğlu, ÖmerThis study evaluates the effectiveness of ionizing radiation in reducing the microbial loads of hospital wastewater, comparing to on-site hospital treatment plant and membrane bioreactor system. The gamma irradiation above 2 kGy significantly outperformed other processes. Gamma treatment at 4.5 kGy provided more efficient treatment with a 4 log reduction in total aerobic mesophilic bacteria, compared to 1.4 and 2.9 log reductions for the on-site and combined on-site/membrane treatment systems. Enterococcus faecium was identified as the most radio-resistant strain. The investigation of dose rate effect on E. faecium inactivation revealed that the D10 value decreased (2.17, 1.49, and 0.76 kGy) with an increase in dose rate (257 Gy/h for gamma-ray, 1087 Gy/h for gamma-ray, and 2500 Gy/s for e-beam). These findings demonstrate that radiation processing offers a robust solution for reducing global health risks associated with hospital wastewater.Item EXPERIMENTAL AND THEORETICAL ASSESSMENT OF SELECTED POLLUTANTS TREATED WITH GAMMA RADIATION AND HYDROGEN PEROXIDE(Türkiye Enerji, Nükleer ve Maden Araştırma Kurumu (TENMAK), 2024-11-28) Genç, Ayşenur; Ergun, Ece; Fitoz, Alper; Kantoğlu, Ömer; İnce, Mahir; Acar, OrhanDegradation of ibuprofen, triclosan, diclofenac, and ketoprofen in real wastewater effluent by gamma radiation/hydrogen peroxide was investigated on the basis of removal efficiencies, G-values, and kinetics. Gamma irradiation was performed using a 60Co source irradiator in the presence of different concentrations of hydrogen peroxide. The analyses of the pollutants were performed before and after irradiation treatment using a Liquid Chromatography-Mass Spectrometry (LC-MS) system. The addition of 0.5% hydrogen peroxide resulted in an enhanced removal efficiency of the target pollutants (93.92% for ibuprofen, 99.47% for triclosan, 86.65% for diclofenac, and 86.32% for ketoprofen) compared with the performance of the gamma irradiation process alone. The rate constants (k) of ibuprofen, triclosan, diclofenac, and ketoprofen increased by 1.42, 2.38, 1.38, and 3.37 times with 0.5% hydrogen peroxide addition, respectively. Moreover, the 90% decomposition of the target pollutants was achieved at lower doses in the gamma-ray/hydrogen peroxide system in comparison with the gamma treatment without hydrogen peroxide. Fukui functions and dual descriptor were calculated using density functional theory (DFT) to investigate the sensitivity of the target pollutants to hydroxyl radical attacks, to identify the initial reaction pathway, and to predict the degradation by-products. The findings were consistent with literature mechanisms and observed by-products.Item Experimental and theoretical assessment of selected pollutants treated with gamma radiation and hydrogen peroxide(ELSEVIER, 2024-12-15) Genç, Ayşenur; Ergun, Ece; Fitoz, Alper; Kantoğlu, Ömer; İnce, Mahir; Acar, OrhanDegradation of ibuprofen, triclosan, diclofenac, and ketoprofen in real wastewater effluent by gamma radiation/ hydrogen peroxide was investigated on the basis of removal efficiencies, G-values, and kinetics. Gamma irradiation was performed using a60Co source irradiator in the presence of different concentrations of hydrogen peroxide. The analyses of the pollutants were performed before and after irradiation treatment using a Liquid Chromatography-Mass Spectrometry (LC-MS) system. The addition of 0.5% hydrogen peroxide resulted in an enhanced removal efficiency of the target pollutants (93.92% for ibuprofen, 99.47% for triclosan, 86.65% for diclofenac, and 86.32% for ketoprofen) compared with the performance of the gamma irradiation process alone. The rate constants (k) of ibuprofen, triclosan, diclofenac, and ketoprofen increased by 1.42, 2.38, 1.38, and 3.37 times with 0.5% hydrogen peroxide addition, respectively. Moreover, the 90% decomposition of the target pollutants was achieved at lower doses in the gamma-ray/hydrogen peroxide system in comparison with the gamma treatment without hydrogen peroxide. Fukui functions and dual descriptor were calculated using density functional theory (DFT) to investigate the sensitivity of the target pollutants to hydroxyl radical attacks, to identify the initial reaction pathway, and to predict the degradation by-products. The findings were consistent with literature mechanisms and observed by-products.Item Nuclear and Analytical Analysis Techniques That Primarily Used to Characterization of Ancient and Historical Materials(Springer, 2026-04-02) Kantoğlu, Ömer; Kalayci, Yakup; Aydin, Büşra; Çantay, Eren; Ergun, Ece; Bulduk Akkuş, Emel; Mert, Yüksel; Kirkayak, Özgü; Gökalp, Metin; Aksu, Erhan; Gündoğdu, GençayCultural artifacts, from ancient manuscripts to historic artworks, are vital symbols of national heritage and identity. The characterization of ancient artifacts is crucial for applying best practices in history and archaeology, including conservation, preservation, investigation, and the prevention of illegal trade. The illicit trafficking of these invaluable objects poses a significant threat to cultural preservation. The effective repatriation of stolen or illicitly exported cultural artifacts heavily relies on non-destructive methods, such as various nuclear and analytical techniques. These methods are critical not only for verifying the authenticity of the artifacts but also for establishing their provenance and legal ownership. This chapter explores the importance of analytical methods in the repatriation process applied in all over the world, highlighting their impact on the successful return of cultural treasures to their rightful owners.