The effect of 4 - dimethylaminoazobenzene (DAB) on the mitochondria of the cells cultivated in tissue culture II - the effect of 4 - dimethylaminoazobenzene (DAB) on mitochondrial enzymes

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dc.contributor.authorEnginün, Mine
dc.contributor.authorÜçer, Ertan
dc.contributor.departmentTAEK-ÇNAEMtr_TR
dc.date.accessioned2017-10-20T07:52:07Z
dc.date.available2017-10-20T07:52:07Z
dc.date.issued1973
dc.descriptionTENMAK D.N.. 10344tr_TR
dc.description.abstractİyi bilinen bir karsinojen olan 4-dimetilaminoazobenzen’in (DAB) embriyonik sıçan hücrelerinin mitokondriumları ve mitokondrial Isositrat (ICDH) ve glutamat (GLDH) dehidrogenazlar üzerindeki tesiri histokimyasal olarak araştırılmıştır. 0.1 mg DAB ihtiva eden vasatta embriyonik sıçan hücreleri 1.5, 3, 5 ve 24 saat inkübe edildiklerinde, yüksek enzim aktivitesi gösteren mitokondriumların sayılarının arttığı müşahade edilmiştir. Vasattan DAB nin çıkarılması halinde bilhassa ICHD aktivitesinin aşağı yukarı normal hücrelerde görülen seviyeye düştüğü görülmüştür, ki bu da hücrelerin ve enzimlerin ortamdan DAB nin kalkmasıyla yeniden eski hallerini alabildiklerini göstermektedir.tr_TR
dc.description.abstractThe effect of 4-dimethylaminoazobenzene (DAB), a well known carcinogen, on the mitochondria of the rat cells and on the mitochondrial dehydrogenases was investigated histochemically. Isocitrate (ICDH) and glutamate (GLDH) dehydrogenases were the selected mitochondrial enzymes for investigation. Incubation of embryonic rat cells in medium containing 0.1 mg of DAB for various hours; namely 1.5, 3, 5 and 24 hours; resulted in increased number of mitochondria exhibiting higher enzyme activity. Removal of the DAB from the medium resulted in decrease of the enzyme activity down to approximately normal level, especially in the case of ICHD; indicating a recovery of some sort.tr_TR
dc.identifier.citationEnginün, M. ve Üçer, E. (1973). The effect of 4 - dimethylaminoazobenzene (DAB) on the mitochondria of the cells cultivated in tissue culture II - the effect of 4 - dimethylaminoazobenzene (DAB) on mitochondrial enzymes. İstanbul : T.A.E.C., Çekmece Nuclear Research And Training Center.tr_TR
dc.identifier.urihttp://kurumsalarsiv.tenmak.gov.tr/handle/20.500.12878/619
dc.language.isoengtr_TR
dc.publisherT.A.E.C., Çekmece Nuclear Research And Training Centertr_TR
dc.relation.ispartofseriesT.A.E.C., Çekmece Nuclear Research And Training Center;ÇNAEM - R - 118
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subjectDimetilaminoazobenzen (DAB)tr_TR
dc.subjectDimethylaminoazobenzene (DAB)tr_TR
dc.subjectTissue culturetr_TR
dc.subjectDoku kültürütr_TR
dc.subjectBenzentr_TR
dc.titleThe effect of 4 - dimethylaminoazobenzene (DAB) on the mitochondria of the cells cultivated in tissue culture II - the effect of 4 - dimethylaminoazobenzene (DAB) on mitochondrial enzymestr_TR
dc.title.alternative4-Dimetilaminoazobenzen’in (DAB) doku kültüründe yetiştirilen hücrelerin mitokondriumları üzerine etkisi II- 4-dimethylaminoazobenzen’in mitokondrium enzimleri üzerine etkisitr_TR
dc.typereporttr_TR
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