Preparing 99mTc labeled magnetite nanoparticles as drug carriers
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Date
2006
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Azerbaijan National Academy of Sciences Institute of Radiation Problems ve Turkish Atomic Energy Authority
Abstract
Dextran coated 99mTc labeled magnetite nanoparticles were prepared in this study. Magnetite was synthesized by a coprecipitation reaction that occurs upon mixing 0.37 g FeCl3, 1.51 g FeCl24H20 with dextran T-40 (50w%, 10 ml, MW 40000). NH4OH solution (7.5% w/v) was added up to pH 10. A black magnetite precipitate was formed. Prepared magnetite nanoparticles were labeled using with 74 MBq 99mTcO4 after adding 100 µi (1 mg/ml) freshly prepared SnCl2 solution. Precipitated magnetic carrier particles were centrifuged and washed with pure water until the rinses became neutral. Labeling yield was over 96% and radiochemical purity was approximately 98%. The average size of particles was 150.2±6.1 nm.
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Keywords
99mTc, Tc-99m / Technetium-99m, Teknesyum-99m, Preparing magnetite nanoparticles, Manyetit nanopartikülleri hazırlama, Drug carriers, İlaç taşıyıcılar
Citation
Medine, E. İ. ve Ünak, P. (2006). Preparing 99mTc labeled magnetite nanoparticles as drug carriers. The Fourth Eurasian Conference on Nuclear Science and Its Application : Presentations, (s. 537-538). 31 October-3 November 2006. Baku, Azerbaijan.