A potential new approach for preserving historical artifacts through gamma irradiation and green antimicrobials: Microbiological and theoretical screening

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dc.authorid0000-0001-5645-5571
dc.authorid0000-0002-3556-9462
dc.authorid0009-0008-2938-2969
dc.authorid0000-0002-0403-5425
dc.authorid0000-0002-1830-1181
dc.authorid0000-0002-5461-1005
dc.contributor.authorErgun, Ece
dc.contributor.authorHalkman, Hilal B.D.
dc.contributor.authorKasımfırtına, Eren
dc.contributor.authorKantoğlu, Ömer
dc.contributor.authorErgun, Ümit
dc.contributor.authorOrhan, Ersin
dc.date.accessioned2026-04-28T11:10:49Z
dc.date.available2026-04-28T11:10:49Z
dc.date.issued2025-08-16
dc.departmentTENMAK-Nükleer Enerji Araştırma Enstitüsü-Ankara
dc.description.abstractThis study presents a novel combined treatment process for the decontamination of historical textiles, using gamma irradiation with green antimicrobial agents. Microbiological studies and theoretical approaches were utilized to investigate the effect of treatment processes individually and in combination on isolates from the textile museum. The mean D10 values and the required doses for complete inactivation were found to be 1.19 and 7.60 kGy for bacteria cocktail and 1.47 and 6.32 kGy for mold cocktail, respectively. The antimicrobial activities of two Schiff bases and their reduced derivatives were tested against gamma-resistant microorganisms by measuring the diameter of the inhibition zones. It was found that reduced derivatives exhibited higher antibacterial activity. All compounds were screened through an in-silico study to evaluate the physicochemical properties, drug-likeness, and toxicity profile. Molecular docking studies were performed to investigate the binding affinity of the title compounds against E. coli DNA gyrase B and topoisomerase IV. From the perspectives of both in vitro studies and computational analysis, L4 exhibited the highest biological activity. This finding revealed that the reduction of the imine bond and molecular flexibility have a significant influence on binding to the active site of the biomolecule. Finally, the combined treatment utilizing L4 with gamma irradiation demonstrated a synergistic effect, leading to a 2.6-fold reduction compared to the control, whereas the individual treatments of L4 and gamma irradiation exhibited approximately a 1-fold reduction. This synergistic effect presents an innovative approach to the historical artifact preservation, providing a more efficient and potentially safer decontamination strategy.
dc.identifier.doihttps://doi.org/10.1016/j.radphyschem.2025.113247
dc.identifier.urihttps://kurumsalarsiv.tenmak.gov.tr/handle/20.500.12878/2099
dc.institutionauthorErgun, Ece
dc.institutionauthorHalkman, Hilal B.D.
dc.institutionauthorKantoğlu, Ömer
dc.language.isoen
dc.publisherELSEVIER
dc.relation.journalRadiation Physics and Chemistry 239 (2026) 113247
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIonizing radiation
dc.subjectCultural heritage
dc.subjectAntimicrobial agents
dc.subjectCombined treatment Density functional theory
dc.subjectDensity functional theory
dc.subjectMolecular docking
dc.titleA potential new approach for preserving historical artifacts through gamma irradiation and green antimicrobials: Microbiological and theoretical screening
dc.typearticle
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