Effects of radiation on carbapenems : ESR identification and dosimetric features of gamma irradiated solid meropenem trihydrate
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Date
2006
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor and Francis Ltd.
Abstract
In the present work, effects of gamma radiation on solid meropenem trihydrate (MPT), which is the active ingredient of carbapenem antibiotics, were investigated by electron spin resonance (ESR)spectroscopy.Irradiated MPT presents an ESR spectrum consisting of many resonance peaks.Heights measured with respect to the spectrum baseline of these resonance peaks were used to explore the evolutions of the radicalic species responsible for the experimental spectrum under different conditions. Variations of the denoted 11 peak heights with microwave power, sample temperature and applied radiation doses and decay of the involved radicalic species at room and at high temperatures were studied. On the basis of the results derived from these studies, a molecular model consisting of the presence of four different radicalic species was proposed, and spectroscopic parameters of these species were calculated through spectrum simulation calculations. The dosimetric potential of MPT was also explored and it was concluded that MPT presents the characteristics of normal and accidental dosimetric materials.
Description
Keywords
Elektron spin rezonansı (ESR), Dosimetry, Dozimetri, Temperature, Sıcaklık, Kinetics, Kinetik, Carbapenem, Karbapenem, Meropenem, Electron spin resonance (ESR)
Citation
Tepe, S., Polat, M. ve M. Korkmaz (2006) Effects of radiation on carbapenems : ESR identification and dosimetric features of gamma irradiated solid meropenem trihydrate, Radiation Effects and Defects in Solids, Volume 161, 2006 - Issue 11 Pages 653-664.