Effects of radiation on carbapenems : ESR identification and dosimetric features of gamma irradiated solid meropenem trihydrate

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dc.contributor.authorTepe Çam, Semra
dc.contributor.authorPolat, Mustafa
dc.contributor.authorKorkmaz, Mustafa
dc.contributor.departmentTAEK-SANAEMtr_TR
dc.date.accessioned2017-01-31T11:31:49Z
dc.date.available2017-01-31T11:31:49Z
dc.date.issued2006
dc.description.abstractIn the present work, effects of gamma radiation on solid meropenem trihydrate (MPT), which is the active ingredient of carbapenem antibiotics, were investigated by electron spin resonance (ESR)spectroscopy.Irradiated MPT presents an ESR spectrum consisting of many resonance peaks.Heights measured with respect to the spectrum baseline of these resonance peaks were used to explore the evolutions of the radicalic species responsible for the experimental spectrum under different conditions. Variations of the denoted 11 peak heights with microwave power, sample temperature and applied radiation doses and decay of the involved radicalic species at room and at high temperatures were studied. On the basis of the results derived from these studies, a molecular model consisting of the presence of four different radicalic species was proposed, and spectroscopic parameters of these species were calculated through spectrum simulation calculations. The dosimetric potential of MPT was also explored and it was concluded that MPT presents the characteristics of normal and accidental dosimetric materials.tr_TR
dc.identifier.citationTepe, S., Polat, M. ve M. Korkmaz (2006) Effects of radiation on carbapenems : ESR identification and dosimetric features of gamma irradiated solid meropenem trihydrate, Radiation Effects and Defects in Solids, Volume 161, 2006 - Issue 11 Pages 653-664.tr_TR
dc.identifier.endpage664tr_TR
dc.identifier.issn1042-0150tr_TR
dc.identifier.issue11tr_TR
dc.identifier.startpage653tr_TR
dc.identifier.urihttp://kurumsalarsiv.tenmak.gov.tr/handle/20.500.12878/251
dc.identifier.volume161tr_TR
dc.language.isoengtr_TR
dc.publisherTaylor and Francis Ltd.tr_TR
dc.relation.isversionofhttp://dx.doi.org/10.1080/10420150600903417tr_TR
dc.relation.journalRadiation Effects and Defects in Solidstr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subjectElektron spin rezonansı (ESR)
dc.subjectDosimetrytr_TR
dc.subjectDozimetritr_TR
dc.subjectTemperaturetr_TR
dc.subjectSıcaklıktr_TR
dc.subjectKineticstr_TR
dc.subjectKinetiktr_TR
dc.subjectCarbapenemtr_TR
dc.subjectKarbapenemtr_TR
dc.subjectMeropenemtr_TR
dc.subjectElectron spin resonance (ESR)tr_TR
dc.titleEffects of radiation on carbapenems : ESR identification and dosimetric features of gamma irradiated solid meropenem trihydratetr_TR
dc.typearticletr_TR
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