Is it possible to do radiopharmaceutical quality control with a gamma camera
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Date
2000-10
Journal Title
Journal ISSN
Volume Title
Publisher
Turkish Atomic Energy Authority
Abstract
All of the imaging studies in nuclear medicine start with a suitable radiopharmaceutical
preparation step. In radiopharmaceutical synthesis, an organic or biochemical molecule is
combined with a radioactive element to form a complex. This process is known as radiolabeling
(1). In a radiopharmaceutical labeling study, it is important to realize that whether or not the
radiolabeled chemical complex is in the expected radiochemical form has a vital role for all the
nuclear medicine imaging processes. The common method of radiopharmaceutical quality
control is the chromatographic analysis such as PC, TLC, and HPLC. In nuclear medicine
practice, application of these methods is called radiopharmaceutical quality control(2). The
agrement of results obtained from such chromatographic analysis methods with the criterions
given in United States Pharmacopea (USP) means the regulatory permission of the use of that
radiopharmaceutical in proposed applications^).
In this study separation of several labeled radiopharmaceuticals were demonstrated by using
standard support materials and solvents. After dying the chromatographic support material, a
gamma camera (TOSHIBA GCA-602A) was used to do radiation counting and static imaging
for 2 minutes. These images, then, was divided into rectangular pieces (5 x 25 in pixel) and
Region of Interest (ROI) process was applied to them. The percent labeling yields were
calculated by plotting total count for each area against the number of area. It was also
demonstrated that the Rf values obtained from gamma camera studies were in agreement with
the Rf values obtained with classical methods.
Description
I. Avrasya Nükleer Bilimler ve Uygulamaları Konferansı : 23-27 Ekim 2000. İzmir, Türkiye.
Keywords
Quality control, Kalite kontrol, Gamma camera, Gama kamera, Radiopharmaceutical, Radyofarmasötik
Citation
Taner, M. S. ... [ve arkadaşları]., (2000). Is it possible to do radiopharmaceutical quality control with a gamma camera. I. Eurasia Conference on Nuclear Science and Its Application, Presentations, Vol 1, (s. 574-580). 23-27 October 2000. İzmir, Turkey.