Development of CuO nanoparticles modified electrochemical sensor for detection of salbutamol
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Date
2024-04-29
Journal Title
Journal ISSN
Volume Title
Publisher
Iop Publishing
Abstract
Metal oxide structures are being utilized in an increasing variety of applications. This study used cyclic
and differential pulse voltammetry techniques to investigate the possible utilization of copper oxide
(CuO) nanoparticles modified carbon paste electrode (CPE)for the redox reactions of salbutamol
(SAL). The electrochemical performance of the SAL analyte in a complex matrix environment in
Ventolin was evaluated in order to assess the appropriateness of the proposed sensor in a real sample
environment. CuO nanoparticles were produced via a straightforward, cost-effective and efficient sol–
gel method, and characterization studies of synthesized CuO nanoparticles were performed by
scanning electron microscopy, x-ray Diffraction (XRD), and x-ray photoelectron spectroscopy. The
synthesized CuO nanoparticles had a spherical shape and particle size was found to be 74 nm. The
crystal size of the CuO particles was calculated to be 21.79 nm using the Debye–Scherrer equation.
Under optimal conditions, differential pulse voltammetry demonstrated a linear response in the
50 nM to 100 μM range, with a salbutamol detection limit of 50 nM (S/N = 3). The SAL concentration
(R2= 0.9971)was found to have a good correlation coefficient. The reproducibility of the biosensor
was investigated and evaluated with a relative standard deviation of 3% (n = 8). The storage stability of
CuO modified CPE for two weeks was evaluated based on the response of DP current measured at
intervals every two days. According to the measurement results, the modified electrode exhibited good
stability and reproducibility while maintaining 80% of its stability. It is also a rapid and dependable
sensor candidate with a measurement time of approximately 20 s. The developed electrode has been
utilized successfully to determine doping material with improved performance.
Description
Keywords
:CuO nanoparticles, electrochemical biosensor, metal oxide, salbutamol