Labeling of chlorodiazepoxide with I-131 and biodistribution studies on rats
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Date
2000-10
Authors
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Journal ISSN
Volume Title
Publisher
Turkish Atomic Energy Authority
Abstract
Chlordiazepoxide (CDZ) was labeled with I-131 and investigated its radiopharmaceutical
potential as a benzodiazepine receptor agent. Iodogen was used as iodination agent. Labeling
yields were determined by radio-ITLC (Instant Thin Layer Chromatography) and Paper
Electrophoresis. Labeling yield was approximately 90%. Purification were performed by SepPak C-18 plus. Biodistribution studies were carried out by Albino Wistar rats. I-131 labeled
Chlordiazepoxide which is the 62.2 GBq/mmol specific activity was administered by tail vein
into the rats. Rats were sacrificed by ether narcotization at certain time intervals and the organs
were removed. The brains were dissected into their components. Their activities were counted
by a gamma counter. The activity per gram tissue was calculated and time activity curves were
generated
Description
I. Avrasya Nükleer Bilimler ve Uygulamaları Konferansı : 23-27 Ekim 2000. İzmir, Türkiye.
Keywords
Rats, Fareler, Biodistribution studies, Biyodağılım çalışmaları, Labeling of chlorodiazepoxide, Klordiazepoksidin etiketlenmesi, I-131
Citation
Ünak, P., Yurt, F., Biber, F. Z., (2000). Labeling of chlorodiazepoxide with I-131 and biodistribution studies on rats. I. Eurasia Conference on Nuclear Science and Its Application, Presentations, Vol 1, (s. 581-585). 23-27 October 2000. İzmir, Turkey.