Labeling of chlorodiazepoxide with I-131 and biodistribution studies on rats

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dc.contributor.authorÜnak, Perihan
dc.contributor.authorYurt, Fatma
dc.contributor.authorBiber, F. Zümrüt
dc.contributor.authorID11752tr_TR
dc.contributor.departmentBölüm Yoktr_TR
dc.date.accessioned2018-07-31T09:01:18Z
dc.date.available2018-07-31T09:01:18Z
dc.date.issued2000-10
dc.descriptionI. Avrasya Nükleer Bilimler ve Uygulamaları Konferansı : 23-27 Ekim 2000. İzmir, Türkiye.tr_TR
dc.description.abstractChlordiazepoxide (CDZ) was labeled with I-131 and investigated its radiopharmaceutical potential as a benzodiazepine receptor agent. Iodogen was used as iodination agent. Labeling yields were determined by radio-ITLC (Instant Thin Layer Chromatography) and Paper Electrophoresis. Labeling yield was approximately 90%. Purification were performed by SepPak C-18 plus. Biodistribution studies were carried out by Albino Wistar rats. I-131 labeled Chlordiazepoxide which is the 62.2 GBq/mmol specific activity was administered by tail vein into the rats. Rats were sacrificed by ether narcotization at certain time intervals and the organs were removed. The brains were dissected into their components. Their activities were counted by a gamma counter. The activity per gram tissue was calculated and time activity curves were generatedtr_TR
dc.identifier.citationÜnak, P., Yurt, F., Biber, F. Z., (2000). Labeling of chlorodiazepoxide with I-131 and biodistribution studies on rats. I. Eurasia Conference on Nuclear Science and Its Application, Presentations, Vol 1, (s. 581-585). 23-27 October 2000. İzmir, Turkey.tr_TR
dc.identifier.endpage585tr_TR
dc.identifier.startpage581tr_TR
dc.identifier.urihttp://kurumsalarsiv.tenmak.gov.tr/handle/20.500.12878/751
dc.language.isoengtr_TR
dc.publisherTurkish Atomic Energy Authoritytr_TR
dc.relation.journalI. Eurasia Conference on Nuclear Science and Its Application : Presentations, 23-27 October 2000. İzmir, Turkey.tr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subjectRatstr_TR
dc.subjectFarelertr_TR
dc.subjectBiodistribution studiestr_TR
dc.subjectBiyodağılım çalışmalarıtr_TR
dc.subjectLabeling of chlorodiazepoxidetr_TR
dc.subjectKlordiazepoksidin etiketlenmesitr_TR
dc.subjectI-131tr_TR
dc.titleLabeling of chlorodiazepoxide with I-131 and biodistribution studies on ratstr_TR
dc.typeconferenceObjecttr_TR
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I. Eurasia conference on nuclear science and its application : presentations, 23-27 October 2000. İzmir, Turkey.