Labeling of cholecystokinin with 99mTc and investigation of its radiopharmaceutical potential

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dc.contributor.authorErtay, T.
dc.contributor.authorÜnak, Perihan
dc.contributor.authorBekis, R.
dc.contributor.authorYurt, Fatma
dc.contributor.authorBiber, F. Zümrüt
dc.contributor.authorDurak, H.
dc.contributor.authorID171211tr_TR
dc.contributor.departmentBölüm Yoktr_TR
dc.date.accessioned2018-07-31T11:41:05Z
dc.date.available2018-07-31T11:41:05Z
dc.date.issued2000-10
dc.descriptionI. Avrasya Nükleer Bilimler ve Uygulamaları Konferansı : 23-27 Ekim 2000. İzmir, Türkiye.tr_TR
dc.description.abstractThe aim of this study is to label CCK8 with Tc-99m and to investigate its radiopharmaceutical potential. CCK8 was labeled with Tc-99m using GH and DTPA as bifunctional chelating agents. Labeling efficiency was higher than 99 %. Complex was stable more than 5 hours. 37 MBq Tc-99m-GH-CCK8 or Tc-99m-DTPA-CCK8 was administered to rabbits intravenously for biodistribution experiments. Dynamic and static images were obtained from anterior projection using a Camstar XC/T gamma camera. For quantitative evaluation, regions of interest were drawn on organs and time-activity curves were generated. The highest accumulation occurred in brain within 10 and 30 minutes after injection. Renal and hepatobiliary excretion were observed. For biodistribution studies on rats, 13.7 MBq Tc-99m-GH-CCK8 or Tc-99mDTPA-CCK8 was administered by tail vein. Rats were sacrificed at 10th minute, 30th minute, 2nd hour and 5th hour and the organs were removed. The rat brains were dissected into their components. The activity/g tissue was calculated. The highest activity was in hypothalamus. Results demonstrated that Tc-99m CCK8 may be a promising radiopharmaceutical for CCK receptor expressing organs.tr_TR
dc.identifier.citationErtay, T., (2000). Labeling of cholecystokinin with 99mTc and investigation of its radiopharmaceutical potential. I. Eurasia Conference on Nuclear Science and Its Application, Presentations, Vol 1, (s. 586-591). 23-27 October 2000. İzmir, Turkey.tr_TR
dc.identifier.endpage591tr_TR
dc.identifier.startpage586tr_TR
dc.identifier.urihttp://kurumsalarsiv.tenmak.gov.tr/handle/20.500.12878/752
dc.language.isoengtr_TR
dc.publisherTurkish Atomic Energy Authoritytr_TR
dc.relation.journalI. Eurasia Conference on Nuclear Science and Its Application : Presentations, 23-27 October 2000. İzmir, Turkey.tr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subjectTc-99m / Technetium-99m
dc.subjectTeknesyum-99m
dc.subjectLabeling of cholecystokinin with 99mTctr_TR
dc.subjectKolesistokinin 99mTc ile etiketlenmesitr_TR
dc.subjectRadiopharmaceuticaltr_TR
dc.subjectRadyofarmasötiktr_TR
dc.subjectPeptidetr_TR
dc.subjectPeptittr_TR
dc.subjectCholecystokinintr_TR
dc.subjectKolesistokinintr_TR
dc.subjectCCK-8tr_TR
dc.subjectTc-99M-GH-CCK8tr_TR
dc.subjectTc-99M-DTPA-CCK8tr_TR
dc.subjectDTPAtr_TR
dc.subjectBiodistribution of CCK8tr_TR
dc.subject99mTctr_TR
dc.titleLabeling of cholecystokinin with 99mTc and investigation of its radiopharmaceutical potentialtr_TR
dc.typeconferenceObjecttr_TR
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I. Eurasia conference on nuclear science and its application : presentations, 23-27 October 2000. İzmir, Turkey.