Preparing an estrogen-derivative compound labeled with Tc-99m and determination of radiopharmaceutical potential
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Date
2000-10
Journal Title
Journal ISSN
Volume Title
Publisher
Turkish Atomic Energy Authority
Abstract
In recent years, estrogen derivative compounds have been used with several purpose which may
lead to rapid advances in both diagnosis and therapy of some human cancers.
In this study, an estrogen derivative compound (ESTCPTA) that 3,17-( β-estradiolyl propinol
attached with 1-(4-methylbenzoic acid)-4,8,11- tetraazacyclotetradecane (CPTA) was
synthesized at five steps. Synthesized product was purified by recrystallization in ethyl alcohol.
Characterizations of purified products were made by NMR and IR spectroscopy. Synthesized
compound was labeled with Tc-99m. RTLC (Radio Thin Layer Chromatography) and radiopaper electrophoresis were used to determine radiochemical yields. Specific activity was
approximately 23.7 GBq/mmol and labeling yield was over 95%.
Biodistribution studies were performed on female Albino Wistar rats. Rats were sacricified by
ether narcotization at certain time intervals and the organs were removed. Their activities were
counted by a gamma counter. The activity per gram tissue was calculated and time activity
curves were generated.
Description
I. Avrasya Nükleer Bilimler ve Uygulamaları Konferansı : 23-27 Ekim 2000. İzmir, Türkiye.
Keywords
Teknesyum-99m, Radiopharmaceutical, Rradyofarmasötik, Estrogen-derivative compound, Östrojen türevi bileşik, Tc-99m / Technetium-99m
Citation
Enginar, H. ... [ve arkadaşları]., (2000). Preparing an estrogen-derivative compound labeled with Tc-99m and determination of radiopharmaceutical potential. I. Eurasia Conference on Nuclear Science and Its Application, Presentations, Vol 1, (s. 638-642). 23-27 October 2000. İzmir, Turkey.