Preparing an estrogen-derivative compound labeled with Tc-99m and determination of radiopharmaceutical potential

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dc.contributor.authorEnginar, Hüseyin
dc.contributor.authorÜnak, Perihan
dc.contributor.authorYurt, Fatma
dc.contributor.authorBiber, F. Zümrüt
dc.contributor.authorID58588tr_TR
dc.contributor.departmentBölüm Yoktr_TR
dc.date.accessioned2018-08-01T07:29:17Z
dc.date.available2018-08-01T07:29:17Z
dc.date.issued2000-10
dc.descriptionI. Avrasya Nükleer Bilimler ve Uygulamaları Konferansı : 23-27 Ekim 2000. İzmir, Türkiye.tr_TR
dc.description.abstractIn recent years, estrogen derivative compounds have been used with several purpose which may lead to rapid advances in both diagnosis and therapy of some human cancers. In this study, an estrogen derivative compound (ESTCPTA) that 3,17-( β-estradiolyl propinol attached with 1-(4-methylbenzoic acid)-4,8,11- tetraazacyclotetradecane (CPTA) was synthesized at five steps. Synthesized product was purified by recrystallization in ethyl alcohol. Characterizations of purified products were made by NMR and IR spectroscopy. Synthesized compound was labeled with Tc-99m. RTLC (Radio Thin Layer Chromatography) and radiopaper electrophoresis were used to determine radiochemical yields. Specific activity was approximately 23.7 GBq/mmol and labeling yield was over 95%. Biodistribution studies were performed on female Albino Wistar rats. Rats were sacricified by ether narcotization at certain time intervals and the organs were removed. Their activities were counted by a gamma counter. The activity per gram tissue was calculated and time activity curves were generated.tr_TR
dc.identifier.citationEnginar, H. ... [ve arkadaşları]., (2000). Preparing an estrogen-derivative compound labeled with Tc-99m and determination of radiopharmaceutical potential. I. Eurasia Conference on Nuclear Science and Its Application, Presentations, Vol 1, (s. 638-642). 23-27 October 2000. İzmir, Turkey.tr_TR
dc.identifier.endpage642tr_TR
dc.identifier.startpage638tr_TR
dc.identifier.urihttp://kurumsalarsiv.tenmak.gov.tr/handle/20.500.12878/763
dc.language.isoengtr_TR
dc.publisherTurkish Atomic Energy Authoritytr_TR
dc.relation.journalI. Eurasia Conference on Nuclear Science and Its Application : Presentations, 23-27 October 2000. İzmir, Turkey.tr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subjectTeknesyum-99m
dc.subjectRadiopharmaceuticaltr_TR
dc.subjectRradyofarmasötiktr_TR
dc.subjectEstrogen-derivative compoundtr_TR
dc.subjectÖstrojen türevi bileşiktr_TR
dc.subjectTc-99m / Technetium-99mtr_TR
dc.titlePreparing an estrogen-derivative compound labeled with Tc-99m and determination of radiopharmaceutical potentialtr_TR
dc.typeconferenceObjecttr_TR
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I. Eurasia conference on nuclear science and its application : presentations, 23-27 October 2000. İzmir, Turkey.