Boron and Zinc Co‑doped Hydroxyapatites for Bone Tissue Engineering Applications

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dc.authorid0000-0002-6063-078X
dc.authorid0000-0002-0991-674X
dc.authorid0000-0002-7518-8162
dc.authorid0000-0003-4292-5856
dc.contributor.authorAkbaba Sema
dc.contributor.authorTuracli Karaguven Senem Ozge
dc.contributor.authorEvis Zafer
dc.contributor.authorTezcaner Aysen
dc.date.accessioned2025-10-27T13:20:04Z
dc.date.available2025-10-27T13:20:04Z
dc.date.issued2025-07-30
dc.departmentTENMAK-Bor Araştırma Enstitüsü
dc.description.abstractIn this study, effects of B and Zn co-doping on structural and biological properties of hydroxyapatite (HA) were investigated. Effect of co-doping on synthesized HA groups was characterized by SEM, ICP-OES, XRD, FTIR, and dynamic light scattering. It was revealed that 8 mol% B led to a decrease in particle size, whereas increasing Zn resulted in increasing mean particle size. FTIR spectra verified presence of PO4 3− and BO3 3− in the HA structure. XRD analysis revealed that both B and Zn decreased HA phase percentage, crystallinity and crystallite size. Bioactivity of the HA groups increased with presence of B and Zn. Dual effect of B and Zn on viability and proliferation of human adipose derived stem cells (hADSCs) was also investigated. It was found that 8 mol% B doped and all B & Zn-doped HA groups increased cell viability and proliferation, except 8 mol% B & 8 mol% Zn doped HA. Moreover, 0.5 mg/ml 8 mol% B & 4 mol% Zn doped HA group significantly increased 14-day ALP activity of hADSCs and vessel area of human umbilical vein endothelial cells (HUVECs). Overall, Co-doping of B (8 mol%) and Zn (4 mol%) to HA provided both proliferative and osteogenic effects on hADSCs and angiogenic effect on HUVECs. Our findings suggest that B and Zn co-doped HA holds promise for bone tissue engineering applications.
dc.identifier.doi10.1007/s12011-025-04756-1
dc.identifier.urihttps://kurumsalarsiv.tenmak.gov.tr/handle/20.500.12878/2077
dc.institutionauthorAkbaba, Sema
dc.language.isoen
dc.publisherSpringer Nature
dc.relation.journalBiological Trace Element Research
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAngiogenesis
dc.subjectBone tissue engineering · Boron · Hydroxyapatite · Zinc
dc.subjectBoron
dc.subjectHydroxyapatite
dc.subjectZinc
dc.titleBoron and Zinc Co‑doped Hydroxyapatites for Bone Tissue Engineering Applications
dc.typearticle
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