Preparation and characterization of various column-filling materials in order to optimize 68Ge-68Ga generator column
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Date
2024-06-15
Journal Title
Journal ISSN
Volume Title
Publisher
T.C. Türkiye Enerji, Nükleer ve Maden Araştırma Kurumu
Abstract
In order to obtain ready-to-use 68Ga in Positron Emission Tomography (PET) applications, the 68Ge/68Ga
generator system is an ideal source and allows PET imaging in centers without cyclotrons.
Radiochemical separation of Ge (mother) and Ga (daughter) radionuclide though commercial generators
is carried out with columns consisted of inorganic metal oxides. In this study, commercially available
tin dioxide (SnO2), laboratory-synthesized SnO2, titanium dioxide (TiO2) and zeolite as a column filling
material in 68Ge/68Ga generators were used. The sorption behavior of column-filling materials as
adsorbent was investigated without the use of radioactive materials. All elements, especially Ge and Ga
for representing 68Ge/68Ga generator system, were performed using Inductively Coupled Plasma Mass
Spectrometry (ICP-MS). In addition, since these column-filling materials used in the thesis will be
exposed to radiation during the shelf life of the 68Ge/68Ga generator, their radiation stability were
investigated. Structural characterization studies were performed with, Raman Spectroscopy, Fourier
Transform Infrared Spectroscopy (FTIR) and X-ray Diffraction (XRD). In order to calculate surface
area and pore sizes, Brunauer-Emmett-Teller (BET) method were used. The promising results obtained
in this study, calcined at 900 °C Kw_SnO2 would be prepared and evaluated of pilot 68Ge/68Ga
generators.
Description
Keywords
radionuclide, 68Ge/68Ga Generator, metal oxide, adsorption, Positron Emission Tomography, (PET)